By Allison Proffitt 

August 27, 2024 | Before a record-breaking Bioprocessing Summit crowd last week, Chromatan was named the 2024 Bioprocessing Summit Best of Show People’s Choice Awards grand prize winner. Their BioRMB Kascade column-free chromatography system was chosen as the best new product on display at the event by the Bioprocessing Summit community. The BioRMB Kascade system is a column-free purification system that enables true steady-state continuous processing with a full closed single-use flow path, the company said.  

The Bioprocessing Summit Best of Show People’s Choice Awards seeks to recognize the most innovative new products in the bioprocessing space. The award program is open to all Bioprocessing Summit exhibitors with new products released since the last event. Exhibiting companies enter their new products and display them at the event and event attendees are invited to vote on their favorites.  

This is the second year that a Best of Show awards program has been held at the Bioprocessing Summit. Last year’s winner was RedShiftBio’s HaLCon. More information about the awards program can be found here.  

Chromatan’s award-winning platform runs at low pressure and achieves 10x-20x improvements in productivity as well as higher recovery and better product quality vs status quo column technologies, the company said.  

2024 Best of Show finalists:  

Chromatan | BioRMB column-free Chromatography System  
The newly launched BioRMB Kascade system is the first of its kind column-free purification system that enables true steady-state continuous processing with a full closed single-use flow path. The platform runs at low pressure, and is able to achieve 10-20X improvements in productivity as well as higher recovery and better product quality vs status quo column technologies. 

Cytvia | Supor Prime sterilizing grade filters  
Supor Prime filters are specifically designed for the sterile filtration of high-concentration biotech drugs. Two unique membranes are utilized in these filters to ensure high capacity and high flow rates for viscous feeds and high fouling fluids. The innovative capsule design ensures that it can withstand high pressure and is easy to use. The scalability of the filter ensures predictable results through the range. Supor Prime delivers double the throughput when compared to competitor filters. Downstream (DSP) and formulation-and-fill (F&F) process development scientists and managers will benefit from using Supor Prime filters as it helps them implement smaller filters, reducing the volume of product entrained in the membrane, and maximizing product recovery/yield. These filters are primarily used for sterile filtration of high concentration mAbs post UF/DF, prior to bulk drug substance, and prior to final drug product. Customers may also see the benefits of use in other high value to products such as liposomes, exosomes, other lipid nanoparticles as well viral vectors. 

MACHEREY-NAGEL, Inc. | NucleoBond RS 200  
NucleoBond RS columns are designed for large-scale isolation of vaccine-grade plasmid DNA from bacterial cultures, utilizing peristaltic pumps or FPLC systems. By implementing the NucleoBond RS workflow, you can achieve endotoxin levels ≤ 0.01 EU/µg DNA, ensuring compliance with stringent regulatory standards. The closed columns are available in four different sizes, enabling a straightforward scalability. Additionally, the columns and plasmid isolation workflow can be processed completely free of materials of animal origin. 

Refyn | KaritroMP Version number: 1  
The new KaritroMP is a benchtop instrument that characterizes large viral vectors. Ideal for informing process development in preclinical settings and early drug development, it analyzes samples of adenovirus vectors (AdV) and lentivirus vectors (LVV) in just minutes. The instrument offers essential vector analysis capabilities, including the assessment of sample purity and stability. ​ Using novel macro mass photometry technology, this pioneering tool performs single-particle analysis, enabling users to visualize distributions of viral particle populations within their samples. It can resolve distinct populations of vectors and reveal changes over time – indicating whether a sample is suitable for further processing and helping users save time and resources. 

Repligen | TangenX SC TFF Device  
TangenX SC TFF Device: Revolutionize tangential flow filtration processes Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time, eliminating decommission time and minimizing product loss risk. TangenX SC self-contained TFF devices are designed to address your downstream filtration needs: 1. Easy-to-use True Flat Sheet Device: TangenX SC is your plug-and-play solution reducing the setup time by a remarkable 80% because no holder is required. Say goodbye to the multi-step setup procedures and torquing required by traditional cassettes and holders 2. Scalable: TangenX SC devices are scalable within the product family and designed to be cross-scalable with TangenX SIUS single-use cassettes and TangenX PRO reusable cassettes by maintaining the same flow path length and height 3. Improved Productivity: With TangenX SC, the filters are contained within the device ensuring the integrity of your process and minimizing the risk of product loss 4. Reduced Process Support Time: TangenX SC eliminates torquing before and during a run and simplifies decommissioning, allowing you to focus on what matters - your process and facility efficiency 5. Consistent TFF Cassette Performance: With the same high performing membranes and channel geometry and flow path length as other TangenX cassettes formats, you can expect the same exceptional TFF performance with TangenX SC 

RheoSense, Inc. | m-VROC II  
The original m-VROC was officially released in 2009. It's been 13 years since our flagship viscometer was released and we have hundreds of customers using the viscometer to this day. Today, RheoSense, Inc. is proud to introduce the new m-VROC II, the high-precision, industry-leading small sample viscometer - measuring viscosity for sample volumes as small as 10 microliters! Still utilizing first principle, the second generation m-VROC measures viscosity with the highest accuracy (2% of reading) and repeatability (0.5% of reading), but is now equipped with sample retrieval, recovery, and automated cleaning. Sample retrieval refers to the reversal of flow to refill the test syringe with a portion of the loaded volume. The retrieval process allows for more extensive testing on a single loaded sample volume which can include multiple repeats, shear rates, and temperatures. Sample recovery involves a final retrieval of the entire volume back into the test syringe so that the sample can be retained for further testing. m-VROC II measures shear rate ranges from 0.86 ~ 2,020,000 across a wide temperature range (4-70°C) and can run a single sample measurement in under a minute! The m-VROC II comes equipped with an intuitive software, allowing users to easily save and load protocols, perform shear rate and temperature sweeps, export data into PDF/Excel, and apply non-Newtonian corrections with the push of a button. This intuitive software is also 21 CFR part 11 compliant, providing multi-level user access (standard user, IT admin, super admin etc.) and ensuring data integrity, preventing users from potentially manipulating your data. With the extreme repeatability and small footprint of VROC technology, m-VROC II the ideal tool for all your research and routine viscosity measurements. 

Scientific Bioprocessing | Multiparameter Sensor (MPS)  
As the central piece of sbi’s DOTS Platform, the Multiparameter Sensor (MPS) enables effortless online monitoring of multiple parameters in shake flasks. From dissolved oxygen (DO) and biomass monitoring to fluorescence detection – the MPS turns the standard shake flask into a smart bioreactor. Save time and money with automated, online monitoring of many shake flasks in parallel. The DOTS Software provides real-time, actionable insights from all your shake flasks. 

 
Sphere Fluidics | Cyto-CellectPLUS  
In June 2024, Sphere Fluidics launched Cyto-CellectPLUS. In conjunction with the Company’s Cyto-Mine platform, the next-generation assay provides a streamlined and cost-effective complete solution to measure antibody production in single cells by rapidly detecting secreted human IgG, enabling the identification and selection of cells with the highest productivity for more efficient cell line development. Cyto-CellectPLUS is a robust and easy-to-use Fluorescence Resonance Energy Transfer (FRET) assay that enables researchers to quantify IgG productivity with high sensitivity. Expanding on Sphere Fluidics’ original successful Cyto-Cellect Human IgG kappa (IgGκ) Detection Kit, Cyto-CellectPLUS now detects both the IgG kappa (κ) and lambda (λ) light chains to support a broader range of projects. The assay is fully compatible with existing Cyto-Mine functionality, including single cell dispensing into 96-well and 384-well plates, allowing it to seamlessly integrate into customers’ existing cell line development workflows and conforms to relevant regulatory requirements by being animal-origin-free. Cyto-Mine is an automated platform which integrates single cell screening, sorting, dispensing, imaging, and clone verification in one bench-top instrument. Underpinned by the Company’s patented, droplet-based microfluidic technology, it can automatically screen up to 40 million cells in a matter of hours, compared with 10,000 typically achieved using multi-step manual techniques. This accelerated throughput is already widely recognized across a variety of research areas, including antibody discovery, cell line development, cell engineering and synthetic biology. The platform also facilitates rapid, high-throughput single cell manipulation and analysis across an expanding range of emerging research areas, including precision genome editing and cell therapy. 

Varya Virtual| iota - 2.0.10  
Iota, the flagship product from Varya Virtual, is an innovative data management platform tailored for the pharmaceutical and biotech industries. Built on Microsoft 365, Iota excels in handling complex datasets with unmatched efficiency and security. It integrates advanced features like data curation, ontology modeling, and artifact generation, providing real-time insights and fostering seamless collaboration. Iota’s ability to capture complete data lineage ensures transparent, traceable records, driving innovation and enhancing global health outcomes. With Iota, streamline your research, maintain compliance, and accelerate discovery. Technical Specifications: - Platform: Microsoft 365 - Data Curation: Comprehensive tools for data collection and management. - Ontology Modeling: Track and maintain experimental data throughout the drug development process. - Artifact Generation: Automated creation of actionable insights. - Chain of Custody: Transparent and traceable data records. - Data Integrity: Ensures accuracy and protection from unauthorized changes. - Real-Time Insights: Rapid data analysis for informed decision-making. - Collaborative Tools: Enhanced features for teamwork and data sharing. - Compliance and Security: Adheres to industry regulations and high data quality standards. - Accelerated Insights: Speeds up research processes and delivery of results. Applications: - Pharmaceutical Research - Biotech Innovation - Data-Intensive Fields