Cambridge Healthtech Institute’s 11th Annual
Advances in Purification & Recovery
Optimizing Downstream Efficiency
August 20-21, 2025
Join us at the Advances in Purification & Recovery conference, where leaders in bioprocessing come together to shape the future of downstream innovation. This event dives into cutting-edge solutions for purification and recovery, featuring breakthroughs in chromatographic techniques, non-chromatographic innovations, and strategies for novel modalities like bispecific antibodies, RNAs, and gene therapies. With a focus on scalability, efficiency, and digital process optimization, this conference offers actionable insights to tackle today’s bottlenecks and advance bioprocessing technologies.
Coverage will include, but is not limited to:
- Advances in Chromatographic Approaches
- Advances in chromatography resins, membrane adsorbers, and affinity tags
- New substrates and new monoliths (e.g., AAVs) for more complex biologics
- Innovations in ligand design—mixed-mode and ligand-specific resins for non-mAb purification
- High-throughput chromatographic screening (e.g., microfluidics)
- Multi-modal chromatography for improved separation efficiency
- Replacement of Protein A for Fc-less and complex molecules (e.g., ProteinL for bispecifics purification)
- Non-Chromatographic Innovations
- Use of alternative capture methods (e.g., nanoparticle filtration, precipitation, crystallization)
- Aqueous 2-phase extraction for gene therapies
- Ultrafiltration/depth filtration for antibody-drug conjugates
- Magnetic separation
- Non-affinity precipitation and filtration for non-mAbs (e.g., cytokines, fusions, or scFvs)
- Membrane fiiltration of mRNA
- Purification for Novel Modalities:
- Challenges in purifying bispecific antibodies (homo dimers vs. heterodimers, higher aggregation levels), fusion proteins, cytokines, TCRs
- Purification for gene delivery (e.g., AAVs, lentiviruses, adenovirus, non-viral vectors)
- Continuous crystallization of gene edited therapies—RNA (single-chain vs. double-chain, linear, and circular RNA), nuclease (CRISPR, ZFN, talen)
- Exosome and extracellular vesicles purification
- Viral filtration for gene therapies
- Scalability, Process Optimization, and Digital Twins
- Scaling up downstream processes while maintaining product quality and yield
- Integration of formulation and fill/finish steps into continuous workflows
- Mechanistic modeling for scalability assessment
- Digital twins for predictive modeling and process simulation
The deadline for priority consideration is January 27, 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: